Macitentan API And Intermediates
Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.
Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an endothelin receptor antagonist, an antihypertensive agent and an orphan drug. It is an organobromine compound, a member of pyrimidines, an aromatic ether, a ring assembly and a member of sulfamides. It derives from an ethylene glycol and an ACT-132577.
China Macitentan API cas 441798-33-0,Macitentan Intermediate 146533-41-7,Macitentan Intermediate 706811-25-8,Macitentan Intermediate 147962-41-2,Macitentan Intermediate 1393813-41-6, we offered that you can trust. Welcome to do business with us.
Macitentan API cas 441798-33-0,Macitentan Intermediate 146533-41-7,Macitentan Intermediate 706811-25-8,Macitentan Intermediate 147962-41-2 Manufacturers and Suppliers in China  Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com
custom brass forging parts for water meter body
1Â Product Description:
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Description
forging parts
Material
h60
Process
forging+cnc machining+deburrs
Tolerance
+/-0.1mm
Surface treatment
deburrs,degrease,chamfer
Service available
OEM&ODM
Quality control
0 defects,100% inspection before packing
Delivery time
7-25 days
Packing
inner:bubble poly bag,outer:5 layers ctn box or poly wooden box/pallet
Logistics services
sea,air,express,EXW,FOB,CIF,DDU,DDP
Certifications
ISO 9001,SGS
Warranty
100% refund or replacement for NOK pcs
2 Company Information:We(Nanjing Precision Engineering Co.,ltd )are manufacturer for machining services, sheet metal fabrication and mechanical assembles , we have the international trading experience for more than 20 years. our quality system is controlled by ISO9001 , and we have strong engineering team.
We can design the technical drawing for you freely. and even we can send the cnc machining sample within 1-3days, sheet metal fabrication within 3-7days.Â
We are always trying our very best to find the best solutions for the customers together with the competitive price,the good quality, the punctual delivery, the perfect logistics service, and the satisfactory after-sale service.
(1)Vcnc Milling
the workable length
5-12000mm
the workable diameter
5-6000mm
the tolerance
ISO2768-F
the operation system of the machines
FANUC
R&D engineering team design the technical drawings
STP,IGS,PRT,AUTOCAD,PDF...
3D dimensions inspection
STP,IGS,PRT,AUTOCAD,PDF...
the workable length
5-12000mm
the workable diameter
5-6000mm
the tolerance
ISO2768-F
the operation system of the machines
FANUC
R & D engineering team design the technical drawings
STP,IGS,PRT,AUTOCAD,PDF......
2D dimensions inspection
caliper,micrometer,altitude instrument,run-out instrument,roughness instrument.......
Our plastic injection machines could do the mold injection parts and the assembles from 0.005kgs to 1.5kgs,we are also experienced in the stamping,the bending,and the welding,our equipments are advanced in these fields,so we are always doing the exellent fabrication job.In the fabrication,we often use the melting welding,the pressure welidng,and the laser welding,the experienced technicians do the melting welding perfectly,the welding seam is straight,there are no gaps,no holes,no welding slags.All of our welding workpiece could pass the air-tight test successfully,our technicians also do well in the pressure welding and the laser welding,the workpiece is strong and beautiful. The advanced euqipments,the professional R & D engineering team,and the complete inspection facilities enable us to the mechanical assemble with the high good quality level,the mechanical assembles have the good function and the long usage time.
Plating
3+Cr,environmental,anti-corrosion maximum 480 hours salt spray test
Coating
powder coating,electrcial coating,maximum 480 hours salt spray test
Painting
environmental EXPOSY painting,cross-cutting test
Polish
satin polish,mirror polish,electrical polish, maximum 1200 grid
Dacromet
evironmental,anti-corrosion,maximum 560 hours salt spary test
Anodization
tumble,shot blast,sand blast.....,various color,maximum 480 hours salt spray test
Nylok
tight-locking,environmental,5 million times
Heat Treatment
adjust the mechanical properties,temper,normalization,quench......
stainless steel
SS304,SS304L,SS316,SS316L,SS430,SS201......
aluminium
7075,6061,6063,5082,5051,2014......
brass
H62,H58,H59......
steel
C20,C45,C60,C35......
steel alloy
25CrMo,42CrMo,25Cr,40Cr,Q345,11SMn30......
iron cast
QT600,QT250,HT450,HT150......
titanium alloy
GR2,GR5,GR7,GR9......
tungsten alloy
WuNiFe alloy,Carbide Wolfram......
the blanks
stamping parts,forging parts,die casting parts,profile,extrusion......
the plastic
PP,PE,POM,Acrylic,ABS,Delrin......
All the materials are with the material quality certificate,
we are familiar with the international material norm and
the material substitute grade.
ISO 9001-2008
SGS
Material Certificate
CIQ
5 Our Services:
1.R&D service
4.Bulk production service
2.Drawing design service
5.Inspection service
3.Samples service
6.Packing&shipping service
1.Packing:
Inside:bubble bag
Outside:carton case or poly wooden case
2.Shipping:
Small batch by courier, large batch by sea or air
What are our advantage?
1.Price:
Factory competitive price
2.Service:
R&D,OEM&ODM
3.Quality:
ISO-9001,100%QC inspection before packing,0 defects
4.Factory delivery:
7-25 days after comfirm the drawings
5.Business co-operation cultural:
Win-win,non-disclosure agreement,intellectual property protection
If you want to get much more information regarding forging parts, you please feel free to contact with us as following at any time, we are 24 hours online!
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China-Custom-Brass-Forging-Parts-for-Water-Meter-Body
Product Description All the products on our websites can be customized!3 The Company Capabilities:(2)CNC Turning(3) The Fabrication (4) The Mechanical Assemble(5) The Surfact treatment(6) The Variousl Material
4Â Certifications:
6 Packing and shipping:7 FAQ:8 Contact information: